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Year 2002

AU : Kingpetch K, Poshyachinda M, Sirisulipoch S.
TI : Roles of nuclear medicine imaging in diagnosis multiple endocrine neoplasm type 2A.
JN : Asean J Radiol 2002 ; 13 (1) : 77-84 (NO 07618)

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Year 2000

AU : Chaiwatanarat T, Apinyanurak C, Boonjunwetwat D, Chatamra K, Poshyachinda M.
TI : Breast cancer detection with 99mTc MIBI imaging and mammography.
JN : Asean Journal of Radiology 2000 ; 6 : 73-82 (NO 07644)

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Year 1997

AU : Prichakas P, Poshyachinda M, Chaiwatanarat T.
TI : External quality assessment for radioimmunoassay of thyroid and related hormones : third-year scheme.
JN : Chula Med J = ŧóǪChulalongkorn Medical Journal 1997 Aug ; 41 (8) : 575-591
EN-AB: Background : External Quality Assessment Schemes (EQAS) have been widely used in radioimmunoassay (RIA). The International Atomic Energy Agency (IAEA) launched a Regional Co-operative Project on EQAS for radioimmunoassay of thyroid related hormones for deve1oping countries in Asia and Pacific Region. A total of so laboratories from 11 countries in this region including Thailand participated in the scheme. Satisfactory results were reported for the first and second year scheme. The present study is the third year scheme and only results form Bangkok Center will be reported. Objective : The objective of this Regional Cooperative Project is to create interlaboratory surveys for performances on RIA of serum thyroxine (T4), triiodothyromne (T3) and thyroid stimu1ating hormone (TSH) in order to improve accuracy and reliability in their clinical services. Setting : Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Chulalongkorn University Research Design : Prospective study Material : Bangkok Center is one of the 3 designated centers of the scheme. Sixteen laboratories participated in the scheme under responsibility of Bangkok Center. Methods : Three organizing centers prepared 8 EQA pools and randomly distributed 3 EQA samples each month for the whole year to participating laboratories. Participants were requested to assay T4. T3 and TSH in the EQA samples and returned their resu1ts batch by batch. Monthly and six-monthly results were analyzed and the results were returned to participants. Result : The overall results of the present EQAS demonstrate considerable improvement in TSH assay performance as compared to previous scheme and further improvement is evidenced for T3 and T4 assay. Conclusion : The present EQAS indicates further improvement in performance of radioimmunoassay in most participating laboratories. (NO 05087)

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Year 1996

AU : Poshyachinda M, Chaiwatanarat T, Saesow N, Thitathan S, Voravud N.
TI : Value of radioimmunoscintigraphy with technetium-99m labelled anti-CEA monoclonal antibody (BW431/26) in the detection of colorectal cancer.
JN : European Journal of Nuclear Medicine 1996 ; 23 (6) : 624-30
EN-AB: This study was undertaken as part of a Coordinated Research Programme initiated by the International Atomic Energy Agency to evaluate the usefulness of radioimmunoscintigraphy (RIS) in the management of patients with colorectal cancer. Technetium-99m labelled BW431/26, a monoclonal antibody against carcinoembryonic antigen (CEA), was used. The study included 73 patients (31 females and 42 males). Sixty-eight patients were suspected of having recurrent colorectal adenocarcinoma while another five were suspected to have primary colorectal cancer. Images were acquired at 10 min and 4 and 24 h following the injection of radioantibody. The efficacy of RIS in tumour detection was evaluated by the findings at surgery, histological investigation and/or other diagnostic modalities and clinical follow-up. Four of five patients with suspected primary colorectal cancer gave true-positive results (three at primary sites, one at the site of a metastatic lesion) while one was false-positive. The overall accuracy of RIS in the diagnosis of recurrent colorectal cancer was 87. Its sensitivity in the detection of locoregional or abdominal recurrence and liver metastases was 97 and 89 respectively. RIS was more accurate than computed tomography (CT) scan in the detection of pelvic recurrence and liver metastases while CT scan was far superior to RIS in detecting lung metastases. RIS proved most useful in patents who had rising CEA levels on clinical follow-up but in whom other work-up, including CT scan, was negative. The advantages of RIS include the ability to detect tumour recurrence prior to other investigations and to identify tumour recurrence in areas such as the pelvis, where CT and magnetic resonance imaging have their greatest weaknesses in diagnosing recurrent disease. The imaging accuracy is significantly increased when combined CT and antibody imaging is performed. (NO 02843)

AU : Ե ó.
TI : PACS and teleradiology (editorial).
JN : ŧóǪ = Chula Med JChulalongkorn Medical Journal 1996 Apr ; 40 (4) : 265-267 (NO 04441)

AU : Suwanwela N, Can U, Furie KL, Southern JF, Macdonald NR, Ogilvy CS, Hansen CJ, Buonanno FS, Abbott WM, Koroshetz WJ, Kistler JP.
TI : Carotid Doppler ultrasound criteria for internal carotid artery stenosis based on residual lumen diameter calculated from en bloc carotid endartercetomy specimens.
JN : Stroke 1996 Nov ; 27 (11) : 1965-1969
EN-AB: BACKGROUND AND PURPOSE: Carotid duplex ultrasound is widely used to screen patients for carotid endarterectomy and if combined with MR angiography and transcranial Doppler may be an alternative to conventional angiography in the preoperative assessment. We have examined the correlation between Doppler velocities and the residual lumen diameters of internal carotid arteries from surgical pathological specimens to establish Doppler criteria for residual lumen diameter independent of percent stenosis. METHODS: Ninety-one patients who underwent 99 carotid endarterectomies for internal carotid artery stenosis within 6 months of their carotid duplex ultrasound evaluation were studied. The endarterectomy specimens were removed en bloc, and the minimal residual lumen diameter was calculated by computer analysis. The sensitivity and specificity of the Doppler criteria for determining high-grade stenosis were calculated and receiver -operator curves generated. RESULTS: Peak systolic velocity (PSV), end-diastolic velocity (EDV),and carotid index (peak internal carotid artery velocity/common carotid artery velocity) correlated with the residual lumen diameter. PSV 440 cm/s, EDV 155 cm/s, or carotid index 10 indicated a residual lumen diameter of or 200 cm/s combined with either an EDV 140 cm/s or a carotid index 4.5 has a sensitivity of 96% and a specificity of 61%. CONCLUSIONS: Doppler criteria can be both specific and sensitive for detecting a significant stenosis, defined as a or (NO 04582)

AU : Poshyachinda M, Chaiwatanarat T.
TI : Assessment of bone mineral density in normal Thais.
JN : Asean Journal of Radiology 1996 ; 2 (1) : 1-12 (NO 04921)

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Year 1995

AU : Chaiwatanarat T, Poshyachinda M, Saesow N.
TI : Comparison of in-house Tc-99m DTPA and commercial Cr-51 EDTA for measurement of glomerular filtration rate in patients.
JN : Chulalongkorn Medical Journal 1995 ; 39 (6) : 437-442
EN-AB: The use of creatinine clearance in evaluation of glomerular filtration rate (GFR) has many disadvantages. Alternatively, GFR can be determined by more reliable methods such as plasma clearance of Cr-51 ethylenediamine tetraacetic acid (Cr-51 EDTA) or Tc-99m diethylenetriamine pentaacetic acid (Tc-99m DTPA). Cr-51 EDTA, which gives a more accurate GFR result is very expensive and has to be imported. On the other hand, Tc-99m DTPA is cheaper and can be prepared in any nuclear medicine laboratory. To evaluate the quality of DTPA that was prepared at our laboratory, the plasma clearance of Tc-99m DTPA was compared with that of imported Cr-51 EDTA in 40 patients with various diseases. Using a double compartmental multiple blood samples method, the correlation coefficient(r) of the two radiopharmaceuticals was 0.93 with a standard error of estimation (Sx.y) of 12.1ml/min. The p value of a paired t-test was 0.65. We conclude that our in-house Tc-99m DTPA has a comparable quality to that of imported Cr-51 EDTA in the measurement of glomerular filtration rate. (NO 02616)

AU : Է ٵС, ɰ Եժ, Ҥͧ ШԹ, ҭ ⾪ء, ٵС, Ѫ Ѳ, Ѳ, Ѫ Ѳѵ, ѵ ѭ.
TI : ԴԢͧؼʹʹʡѺ÷.
BK : ä ҸԷ ѡ: ͧ (óҸԡ) 1995 : 347-357 (NO 03739)

AU : Suwanwela N, Suwanwela C.
TI : Imaging of fronto-ethmoidal encephalomeningocele.
JN : Neuroradiology 1995 ; 37 (Suppl) : 271-273 (NO 04934)

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Year 1994

AU : Chaiwatanarat T, Laorpatanaskul S, Poshyachinda M, Boonvisut S, Buachum V, Krisanachinda A, Suvanapha R.
TI : Deconvolution analysis of renal blood flow: evaluation of postrenal transplant complications.
JN : Journal of Nuclear Medicine 1994 Nov ; 35 (11) : 1792-6
EN-AB: Medical complications after renal transplantation cause problems in treatment decision making. To differentiate acute tubular necrosis from acute rejection when it occurs in the early posttransplant period is difficult. Renal scintigraphy offers a noninvasive means for renal blood flow (RBF) and renal function assessment. METHODS: This retrospective study of RBF and renal function evaluation after kidney transplantation is an attempt to calculate the "renal vascular transit time" from the 99mTc-diethylenetriaminepentaaacetic acid renal vascular flow with a deconvolution technique. The results of 102 studies on 38 graft recipients were evaluated. Of these, 19 were diagnosed as acute rejection, 12 as acute tubular necrosis, 4 as chronic rejection, 1 as vesicoureteric reflux, 1 as recurrent immunoglobulin A nephropathy, 1 as iliac vein thrombosis, 1 as cyclosporine nephrotoxicity and 63 as normal. All diagnoses were established by clinical and/or pathologic criteria. RESULTS: With renal vascular transit times more than 12.8 secm the sensitivity and specificity for the detection of acute rejection was 95 and 94, respectively. The sensitivity and specificity for the differential diagnosis of acute rejection against acute tubular necrosis was 95 and 92, respectively. CONCLUSION: The use of renal vascular transit time in addition to 131I-labeled hippuran renogram provides a promising diagnostic parameter to differentiate between acute rejection and acute tubular necrosis. (NO 02258)

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Year 1993

AU : Futrakul P, Poshyachinda M, Futrakul N, Chaiwatanarat T, Sensiriwatana R, Watana D, Kingwatanakul P.
TI : Therapeutic comparison between vasodilators and conventional therapy in severe form of nephrosis associated with focal segmental glomerulosclerosis.
JN : Chulalongkorn Medical Journal 1993 ; 37 (11) : 673-678
EN-AB: 14 nephrotics associated with FSGS clinically classified as severe were subjected to intrarenal hemodynamic assessment. The intrarenal hemodynamics characteristic of severe FSGS were as follows. (1) marked elevation of efferent and efferent arteriolar resistances; RA or RE above 10,000 dyne.s.cm-5 (normal 2000-2600 dyne.s.cm-5) (2) more than 50 per cent reduction of ultrafiltration coefficient; KFG less than 0.03 ml/sec/ mmHg (normal 0.06 ml/sec/mmHg) (3) more than 50 per cent reduction of renal plasma flow; RPF less than 250 ml/min/1.73 m2 (normal 500-660 ml/min/1.73 m -2) (4) more than 50 per cent reduction of glomerular filtration rate; GFR less than 50 ml/min/ 1.73 m 2 (normal 100-120 ml/min/1.73 m2) (5) intraglomerular capillary hypertension; PG more than 55 mmHg (normal 47-54 mmHg) Therapeutic comparison between the 8 conventionally-treated (prednisolone + cyclophosphamide) and 6 vasodilator-treated (antiplatelet + calcium channel blocker + angiotensin converting enzyme inhibitor) revealed that all in the former developed end-stage renal disease and deceased whereas all in the late showed progressive clinical improvement and survived. (NO 02800)

AU : Intragumtornchai T, Arjhansiri K, Posayachinda M, Kasantikul V.
TI : Obstructive uropathy due to extramedullary haematopoiesis in beta thalassaemia/haemoglobin E.
JN : Postgraduate Medical Journal 1993 Jan ; 69 (807) : 75-77
EN-AB: An 18 year old woman with beta thalassaemia/haemoglobin E developed a large pelvic tumour resulting in bilateral obstructive uropathy. Technetium-99m sulphur colloid marrow image, computed tomographic scan of the abdomen and needle biopsy of the mass confirmed the diagnosis of extramedullary haematopoiesis. Although radiation is the treatment of choice for decompression, the mass in this patient did not respond satisfactorily due to its multiple area of tumour autoinfarction. Obstructive uropathy due to extramedullary erythropoiesis has not to our knowledge been previously described. (NO 02887)

AU : Futrakul P, Poshyachinda M, Futrakul N, Chaiwatanarat T, Sensirivatana R, Thamaree S.
TI : Intrarenal hemodynamics alterations and tubular functions in nephrotic syndrome associated with focal segmental glomerulosclerosis (FSGS) : A pathogenetic and therapeutic implication.
BK : Current therapy in nephrology: Andreucci VE, Dal Canton A (eds) Milano: Wichtig Editore, 1993 : 107-114 (NO 03590)

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Year 1991

AU : Poshyachinda M, Buochum V, Prichakas P.
TI : Value of serum thyroglobulin in the follow-up of patients with differentiated thyroid carcinoma.
JN : Chulalongkorn Medical Journal 1991 ; 35 (10) : 631-638
EN-AB: Determination of the serum thyroglobulin (Tg) level has been widely used as a tumor marker in the follow-up of patients with proven differentiated carcinoma of the thyroid. In this study, serial follow-up measurements of the serum Tg levels of 150 differentiated thyroid cancer patients were evaluated to determine the value of this method in patient management. The serum Tg levels determined at intervals of atleast six months in each patient who was followed for a period of one to three years. Whole-body radioiodine scans were also carried out in all patients. The false-positive rate of serum Tg in patients in the remission group was 10.2 percent and the false-negative rate in the group with the disease was 13.1 per cent. The sensivity and specificity of serum Tg was 86.8 per cent and 89.8 per cent, respectively. The serum Tg level was more sensitive than whole-body radioiodine scan, the accuracy of measurement being much increased when these two modalities were combined. Increased discriminative value of serum Tg for the detection of residual cancer was noted in patients who were not on thyroid hormone therapy, but results also proved to be valuable during hormonal treatment. Hence, serum Tg determination is of value in the follow-up of patients and can reduce the frequency of whole-body radioiodine scan. (NO 02692)

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Year 1985

AU : Poshyachinda M, Vajragupta L, Buachum V, Boonvisut S.
TI : Evaluation of radionuclide scintigraphy in intracranial abscess.
JN : J Med Assoc Thai 1985 Mar ; 68 (3) : 117-125
EN-AB: Retrospective analysis of patients with proven intracranial abscesses revealed abnormal radionuclide imaging in 53 of 55 patients (96 per cent) and abnormal cerebral angiography in 40 of 44 patients(91 per cent). Among these patients, 7 subdural abscesses exibited abnormal studies in both modalities. It is concluded that radionuclide imaging is a valuable alternative investigation for diagnosis of intracranial abscess when CT scan is not available. It is recommended that radionuclide angiography should be included in order to improve specificity in diagnosis. (NO 00016)

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Year 1983

AU : Krisanachinda A, Poshyachinda M.
TI : Some aspects of quality control of nuclear medicine instruments at Chulalongkorn Hospital, Bangkok, Thailand.
CONF : Seminar on Quality Assurance in the Use of Nuclear Medicine Instruments, 1982 Jul 19-22, Bangkok, Thailand
JN : Thai J Radiol 1983 Apr ; 20 (1) : 53-59
EN-AB: Division of Nuclear Medicine, Chulalongkorn Hospital Medical School is one of a pilot laboratory for the RCA survey of nuclear instrumentations. The survey program involves the preventive maintenance records and evaluation of instrumentation including the environmental conditions. This communication represents part of the above studies in addition to the evaluation of the quality control tests of the counting and imaging systems of the nuclear medicine equipments in this hospital. (NO 00021)

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Year 1978

AU : Poshyachinda M, Buachum V, Mahasandana S.
TI : Haemolytic side effects of DFD in normal and G-6-PD deficient Thais.
JN : J Med Assoc Thai 1978 Aug ; 61 (8) : 468-480
EN-AB: The study were carried out to determine the haemolytic side effects of 4,4, diformyl diaminodiphenylsulfone (DFD) when administered both in normal and G-6-PD deficient Thais. Haemolysis was observed in only 1 of 11 normal volunteers in whom 1600 mg of DFD was administered. Destruction of glucose-6-phosphate dehydrogenase (G-6-PD) deficient red cells in all 11 normal recipients were demonstrated following varying dosages of DFD ranging from 400-1600 mg. 6 of 12 G-6-PD deficient volunteers who received the same dosage of DFD showed evidence of haemolysis. This finding confirmed the haemolytic effect of this drug. There is no definite evidence concerning the ralationship between severity of the haemolysis and the dosage of DFD or the levels of G-6-PD activity. In conclusion, G-6-PD deficient individuals are much more susceptible to DFD-induced haemolysis than normal persons. (NO 00819)

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Year 1969

AU : Suwanwela C, Poshyachinda V, Poshyachinda M, Suwanwela N.
TI : Radioisotope scanning of the brain.
JN : J Med Assoc Thai 1969 Oct ; 52 (10) : 812-831
EN-AB: Radioisotope scanning of the brain was first introduced at the Chulalongkorn Hospital Medical School, Bangkok, on June 1, 1967. More than 600 scans have been done since. 203Hg-Chlormerodrin was used. The first 300 patients were studied and reported. To facilitate the evaluation of the test, two authors (V.P. and M.P.) reread the scans without knowing the histories or final diagnoses. Among 102 cases with proven diagnoses, there were 67 abnormal, 12 probably abnormal, 11 probably normal and 12 normal scans. Scanning was abnormal in 29 of 32 patients with primary brain tumors. Eight meningiomas, 5 glioblastomas multiforme, 4 medulloblastomas, 4 craniopharyngiomas, 2 astrocytomas and 2 pinealomas all gave abnormal scans. One case each of neurinoma of the facial nerve, pituitary adenoma and ependymoma of the fourth ventricle showed no abnormality in the scans. Localization of tumor was correct in 28 of the 29 abnormal scans. The ability to tell the type of tumor was limited to a small number of meningioma and glioblastoma multiforme. All 8 metastatic brain tumors gave abnormal scans. Among 53 cases of non-neoplastic lesions of the brain, 40 showed abnormal scans. They were abnormal in 12 of the 16 cerebral infarctions which showed wide ranges of isotopic uptake. One patient who had encephalomalacia from cerebral in farction gave so high an uptake that it was misdiagnosed as a meningioma. All 8 brain abscesses and cerebritis showed abnormal scans. Cerebral scars, intracranial hematoma, aneurysm and arterio-venous malformation were also seen with abnormal scans. Differentiation between (NO 01366)

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